Choline: Critical Role During Fetal Development and Dietary Requirements in Adults
نویسندگان
چکیده
منابع مشابه
Choline: critical role during fetal development and dietary requirements in adults.
Choline is an essential nutrient needed for the structural integrity and signaling functions of cell membranes; for normal cholinergic neurotransmission; for normal muscle function; for lipid transport from liver; and it is the major source of methyl groups in the diet. Choline is critical during fetal development, when it influences stem cell proliferation and apoptosis, thereby altering brain...
متن کاملCholine: Dietary Requirements and Role in Brain Development.
Choline is needed for the maintenance of the structural integrity and signaling functions of cell membranes, for neurotransmission, and for transport of lipids and as a source of methyl groups. Choline can be made de novo in the body, but some individuals must also obtain choline in the diet to prevent deficiency symptoms. A number of environmental and genetic factors influence dietary requirem...
متن کاملMaternal dietary choline deficiency alters angiogenesis in fetal mouse hippocampus.
We examined whether maternal dietary choline modulates angiogenesis in fetal brain. Pregnant C57BL/6 mice were fed either a choline-deficient (CD), control (CT), or choline-supplemented diet (CS) from days 12 to 17 (E12-17) of pregnancy and then fetal brains were studied. In CD fetal hippocampus, proliferation of endothelial cells (EC) was decreased by 32% (p < 0.01 vs. CT or CS) while differen...
متن کاملCommon Genetic Variants Alter Metabolism and Influence Dietary Choline Requirements
Nutrient needs, including those of the essential nutrient choline, are a population wide distribution. Adequate Intake (AI) recommendations for dietary choline (put forth by the National Academies of Medicine to aid individuals and groups in dietary assessment and planning) are grouped to account for the recognized unique needs associated with age, biological sex, and reproductive status (i.e.,...
متن کاملLow dietary choline and low dietary riboflavin during pregnancy influence reproductive outcomes and heart development in mice.
BACKGROUND Embryonic development may be compromised by dietary and genetic disruptions in folate metabolism because of the critical role of folate in homocysteine metabolism, methylation, and nucleotide synthesis. Methylenetetrahydrofolate reductase (MTHFR), choline, and riboflavin play distinct roles in homocysteine detoxification and generation of one-carbon donors for methylation. The effect...
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ژورنال
عنوان ژورنال: Annual Review of Nutrition
سال: 2006
ISSN: 0199-9885,1545-4312
DOI: 10.1146/annurev.nutr.26.061505.111156